I once threw up the night before a three-minute speech because I was so nervous.
Doing book readings, signings, etc., however, has forced me to get over my stage fright.
That said, I sure do like a podium to hide behind.
Today, I had a speaking engagement in front of about a hundred people, and when I was asked if I'd like a hands-free mike, I gulped, pulled my shoulders back bravely, and said, "Sure!" I figure if I ever get invited on Oprah or Ellen, I'll have to be comfortable with one. So I pinned the mike to my lapel, fastened the receiver to my belt loop, and gave it my best shot.
It was quite freeing! I was able to point and gesture and wander around while I spoke - although when a joke I told fell a little flat, I didn't have anything to tap and say, "Is this thing on?"